![]() "With elevated IOP being the primary modifiable risk factor affecting the development and progression of glaucoma," said Lee, "This advancement opens up potential avenues for effective and innovative manipulation of the pathway of aqueous outflow using mechanosensors and mechanotransducers. In fact, two such cutting edge machines are now part of Bascom Palmer Eye Institute's Adrienne Arsht Hope for Vision Retinal Degeneration Research Laboratory, which was established with a $1 million gift from philanthropist Adrienne Arsht, given in 2008. Bascom Palmer Eye Institute is one of only a few eye centers in the nation to have its own mass spectrometer. Mass spectrometry is a technique used to identify proteins and to determine their amino acid sequence with great precision and can also ascertain if a protein has been modified. The TM refers to tissue located around the base of the cornea that is responsible for filtering and draining aqueous humor from the eye and controlling the IOP. At the center of this breakthrough lies the protein cochlin, which was discovered in the trabecular meshwork (TM) seven years ago using highly sensitive mass spectrometry. ![]() validates their hypothesis that the response of aqueous humor (fluid produced in the eye) to mechanical stimuli at the cellular level (mechanosensing) impacts the regulation of IOP through cells converting that stimuli into chemical activity (mechanotransduction). The key finding by associate professors of ophthalmology Richard K. ![]() ![]() Miamiā¦ A six-year collaboration between two faculty members of Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine has yielded new insight regarding the regulation of intraocular pressure (IOP) in glaucoma - an irreversible blinding disease that causes progressive visual impairment due to optic nerve damage and is the leading cause of blindness worldwide.
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